The Science Behind Switch – Why It Works So Well

One of the biggest challenges in developing a revolutionary product like Switch, is developing a formula that harmonises with our bodies natural defences to change. The more we try to change, the harder our body fights to keep things the same. This is why psychology is important.

Further to this, and without delving into too detailed an explanation of psychological triggers of ‘change’, Switch successfully harnesses the interplay between the biology and the psychology. This is because Switch triggers very little resistance, which greatly improves its chance of success. As such, the psychology of ‘fortitude’ plays less of a part. Switch is real food that the body readily consumes, providing you good fats, vitamins, minerals, probiotics and micro-nutrients that reduce stress hormones and inflammation. Switch nurtures your body and your brain.

What is GPR41 and how does it influence weight gain and loss?
Scientists have identified a receptor molecule present in the intestinal wall called Gpr41, that, when activated by wastes of gut bacteria, controls the movement of food through the intestine, regulates the nutrient absorption and consequently; weight gain or loss.

In mice, researchers disrupted communication between the bacteria in a ‘control’ group by genetically re-engineering Gpr41 so they were unable to respond. Despite an identical diet, the ‘control’ weighed less and had a leaner build than their ‘non-control’ counterparts.

The active nutrient components of Switch41 pass through the Small Intestine intact. They then combine to promote a healthy and natural fermentation that both cleanses the large intestine and turns off the ‘fat switch’. In recent years, “colon cleansing” has come into fashion as to achieve similar ends by “down-regulating” molecular receptors like GPR41. The challenge with the latter, however, is that it has required a strict diet of mostly high fibrous foods for several weeks to months, as well as periodic fasting. Daily Switch intake, on the other hand, cares for your colon and promotes healthy fermentation, without such dramatic demands on your diet

Healthy WNT Signaling
Scientists have found a molecular switch that controls the formation of fat cells in mice. If the switch is on, fat cells will not develop. If it is off, even would-be muscles cells turn to fat. Research published in Science Magazine investigated two types of mouse cells – precursor muscle cells and precursor fat cells – and identified the fat switch as being a protein known as WNT.

“In the absence of WNT, both cell types consistently differentiated into fat cells.” – lead author of the study, University of Michigan graduate student, Sarah Ross.

WNTS (pronounced “wints”) are a class of proteins, which regulate the complex genetic and biochemical changes that take place during embryological development. When WNT protein binds to a cell membrane receptor, it sets off a chain of biochemical signals, which eventually reach the cell nucleus and either turn on or off genes that regulate development.

Two fat-making transcription factors inside the cell nucleus produce genetic commands for transforming would-be fat cells, called preadipocytes, into fat, or adipocytes. Normally, WNT signaling seems to inhibit these factors. When the cellular signal is turned off, however, the transcription factors are free to make pre-fat cells balloon. Pre-muscle cells (myoblasts) also can turn into fat if WNT signaling is silent. The trouble is that once the cell has developed into fat storing cells there is no reversing these cells. You have to wait until the appropriate cells are replaced.

The cells in our bodies are being replaced all the time but at different rates, (18 months for all of our cells to be replaced). Like Gpr41, the desired WNT signaling is about your body’s processes working in harmony. This is why the Switch provides your body with the Micronutrients, Glyconutrients and soluble fibers to maintain a healthy body and correct communication within your body. Then includes relaxation to lower your cortisol levels at night so that as you sleep, your body rejuvenates with your WNT signaling turned ON.

Fats and fats – good and bad

Fat is important for bodily function and must consume an adequate amount of fat each day. Unfortunately, we fear fat. In turn, many companies have produced fat-free or low-fat products that contain high amounts of sugar or high-fructose corn syrup, both of which increase hunger and cravings for sugary foods. Because fats are an essential part of any meal plan, it is important to recognize them as good or bad.

Bad Fats
All fats are not created equal. The most detrimental fats are hydrogenated ones called trans-fatty acids (also called TFAs or “trans fats”)― most commonly listed as hydrogenated oils or partially hydrogenated oils on food labels ― and should be avoided entirely. Hydrogenation completely alters the liquid oil’s molecular structure so that it no longer resembles a natural fat; in fact, it becomes an unhealthy trans fat. Because the body does not recognize the transformed molecule as a natural fat, it cannot process it and treats it as a toxin. Trans fats can raise levels of low-density lipoproteins (LDLs, commonly known as “bad cholesterol”) and lead to clogged arteries, elevated cholesterol levels, heart disease, type 2 diabetes, and even cancer (Mercola with Droege 2003). The body has no use for trans fats and stores them in fat cells and arteries. Ironically, consuming trans fats actually causes fat cravings that won’t abate until the body receives the essential fatty acids (EFAs) ― the good fats.
Good Fats
Good fats are derived from healthy food sources. Adequate quantities of good fats will fulfil your daily nutritional needs. In fact, the human body cannot survive without some fats—specifically, Essential Fatty Acids (EFAs). EFAs are necessary for the healthy function of every bodily process, including

  • Brain and nervous system activity,
  • Regulation of hormones,
  • Function of organs and the immune system,
  • Cell function, and
  • Digestion.

Unfortunately, our bodies cannot make EFA’s on their own. We have tio source them from the food we eat. The two kinds of EFAs are omega-3 and omega-6. Foods that are high in omega-6 fats are grains, commercially raised meats, oils used in processed foods, and many commonly used cooking oils, including corn, safflower, and sunflower. Omega-3 fats are found in leafy green vegetables, oily fish (like salmon), walnuts, organic eggs, and naturally raised meats. The ideal ratio of omega-3 to omega-6 fats is between 1:2 and 1:4. Unfortunately, because the typical Western diet is abundant in grains and cooked oils and lacking in vegetables and healthy fish, the average omega-6 intake is high and omega-3 intake low. This ratio has been calculated in some people to be as high as 1:50! Clearly, we must make a conscious effort to reduce the amount of omega-6s and increase the amount of omega-3s that we consume to bring that ratio back toward its ideal. Omega-3 fats are vital for the development and maintenance of the adult brain and nervous system. In The Omega Diet, Artemis Simopoulos and Jo Robinson describe a study in which mice fed a diet low in omega-3 fats (i.e., the most common Western diet—lots of carbohydrates; packaged, processed, and fast foods; minimal fruits, vegetables, and whole foods) led to a decreased mental performance compared with mice fed a diet with adequate omega-3s. The same authors state that many behavioural and mood disorders are associated with a lack of omega-3 or an imbalance between omega-3 and omega-6.

Given the general public’s heightened awareness in recent years Omega-3 related benefits, a general trend towards consumption of Omega-3 via capsule supplements has grown almost exponentially; particularly with regard to Omega-3 sourced from marine based food. However, there is a danger in consuming fish oils and it’s compliments as elevated mercury levels is being discovered in significant quantities of fresh fish sold for human consumption.
On the other hand, Switch combines two of nature’s most powerful sources of omega-3s – spirulina and chia seeds – and in the process spares the consumer from exposure to excessive levels of mercury.

The Truth About Saturated Fat
Heart disease was rare before the 1920’s — so rare in fact that the electrocardiograph (which performs the test now commonly known as an electrocardiogram [ECG]), developed to diagnose coronary heart disease, was rejected as a waste of time. By the mid-1950s, however, heart disease was the leading cause of death among Westerns. Today, heart disease leads to as many as 40% of all annual deaths in the United States. In “The Skinny on Fats” (http://www.westonaprice.org/knowyourfats/skinny.html) also in Fallon 2001, well-known nutritional expert Sally Fallon elaborates :

If, as we have been told, heart disease results from the consumption of saturated fats, one would expect to find a corresponding increase in animal fat in the Western diet over the same amount of time as the increase in heart disease. Actually, the converse is true. During the sixty-year period from 1910–1970, the proportion of traditional animal fat in the Western diet declined from 83 percent to 62 percent, and butter consumption plummeted from eighteen pounds per person each year to four. During the past eighty years, the consumption of dietary cholesterol intake has increased only one percent.

If saturated fat consumption actually decreased, then what increased? The answer lies with dietary vegetable oils (margarine, shortening, and refined oils). Vegetable oil consumption increased by approximately 400%, and the consumption of sugar and processed foods increased by about 60% (Fallon 2001). Given the aforementioned, it could be said that saturated fats have been falsely accused of increasing the risk of heart disease. Unfortunately, much of the general public has come to believe otherwise; largely avoiding foods that contain high levels of saturated fat. An example of how ill-informed such behaviour may be we turn to coconut oil. Coconut oils contain primarily saturated fat but no trans fat. Rich in lauric acid, which is known for its antiviral, antibacterial, and antifungal properties, some medical doctors now recommend it as a healthy food oil. In the informative online newsletter Doctor House Call, Al Sears, M.D., elaborates :

“The saturated fat found in coconut oil is a unique fat that helps prevent heart disease, helps to build up the immune system, and does not turn into fat in your body. In fact, it helps to speed up your metabolism… helping you to burn fat and increase your energy!” (Sears no date).

The saturated fat in coconut oil (as well as in palm kernel oil) is of the medium-chain fatty acid (MCFA) variety. The body digests MCFAs more easily and uses them differently than other fats. MCFAs are sent directly to the liver, where they are immediately converted into energy. In other words, the body uses the fat to make energy rather than store it (Fife 2001, 39).

Leptin Signaling and Weight Loss
At first glance, leptin can seem like a confusing and contradictory hormone. Because leptin both suppresses appetite and increases the metabolic rate, you would think that it would be desirable to increase leptin levels.
Instead, in most overweight people, leptin levels are actually excessively high due to leptin resistance, a process similar to that of insulin resistance.
To understand why this is so, we must look at the way a normal weight body is designed to communicate. The process begins when the brain notes the amount of leptin secreted by the cells. If the brain determines these leptin levels are normal, it shuts off the signal to store extra calories as fat. The body no longer feels like eating because the brain, with the help of leptin, has given the full signal.
When our hunter/gatherer ancestors experienced decreased food supply, calories stored as fat were broken down and used as fuel. This caused leptin levels to decline and metabolism to decrease to adjust to the decreased food supply. When food supply once again increased, so too did leptin levels. Once the hunter/gatherer humans had replenished their reserves, leptin signaled our ancestors to stop eating.
In today’s society, however, the foods we eat, the stress we face and the pollution within our environment combine to disrupt the hormonal signals in our bodies. Eventually leptin receptors become desensitized to leptin’s effects and we become Leptin Resistant.
Tyrosine, Calcium and Omega 3 are essential in maintaining effective brain health and ensuring effective communication within your body. Switch41 is a rich natural source of all three while the Xylitol promotes greatly increased calcium absorption.
Improving your Brain Health allows your brain to send a critical message to your body, “Stop Storing Fat!”

How Phytic Acid Fights for Fat Loss

By now, most people are aware of the health problems of the nutritionally depleted processed foods that make up a modern diet. Unfortunately, very little information is provided on the negative roll of the high phytic acid content in both processed and unprocessed foods such as cereals, nuts, legumes and seeds.  These are the very foods that have become a mainstay of today’s diet.

High-phytate (phytic acid) diets result in mineral deficiencies. In populations where cereal grains provide a major source of calories, calcium levels are low resulting in rickets and osteoporosis being common. Calcium deficiency is now a major health problem. Phytic acid also reduces the bodies’ ability to absorb other important minerals, such as iron, magnesium and zinc. The Magnesium, zinc and iron-blocking effects of phytic acid are just as serious as the calcium-blocking effects. For example, one study showed that a wheat roll containing 2 mg phytic acid inhibited Zinc absorption by 18 percent; 25 mg phytic acid in a bread roll inhibited Magnesium absorption by 64 percent. 250 mg inhibited zinc absorption by 82 percent. Also nuts have a marked inhibitory action on the absorption of iron due to their phytic acid content.

Over the long term, when the diet lacks minerals or contains high levels of phytic acid (or both), the metabolism goes down, and the body goes into mineral-starvation mode. The body then sets itself up to use as little of these minerals as possible. Adults will “get by” for decades on a high-phytic acid diet, but “getting by” is why obesity and the early onset of “age related diseases” are now so prevalent.

Growing children though, run into problems early. In today’s nutrient depleted and phytic acid-rich diet, their bodies will suffer from the lower intake of calcium, magnesium and phosphorus with poor bone growth, reduced stature, rickets, narrow jaws and tooth decay. Moreover, iron anemia and reduced mental development may result.

Studies have shown that the foods in Switch, when taken daily, significantly increase the bodies’ levels of; Calcium, Phosphorous, Magnesium, Iron and other Micronutrients. At the same time, they reduce phytic acid so that the body can absorb and utilize these critical minerals.

Probiotics

Probiotics have been dubbed “wonder drugs” with extensive research discovering the friendly bacteria toy provide an effective barrier from a range of health problems.

One hundred trillion bacteria cram inside your body. Scoop them up and they would weigh 1 to 1.5 kg. Linked end-to-end, they would circle the globe two and a half times. Without them, you couldn’t digest any food. But digestion is only part of what these multitaskers accomplish. Thanks to their residence in the intestines, probiotics also help power 60 percent of the body’s immune system. We have evolved with bacteria in our guts – in evolutionary terms bacteria came first and multi-cellular organisms followed. We have learned to live with these bacteria and they provide us with multiple benefits, including providing a source of micro-nutrients. Furthermore, Bacteria are very important for how the immune system develops after birth. It is thought that if without them, we end up with afflictions such as atopic eczema and allergies.

If we can boost the normal, healthy bacteria in the gut then we can prevent these conditions. Also with a healthy, stable and diverse gut flora, it’s quite difficult for a pathogen to come in and establish itself.”

Switch helps you stay healthy by replenishing our intestinal microflora. The probiotics in Spirulina are supported by Xylitol (beneficial bacteria). Also, the high fiber content of Chia assists in cleansing the intestinal walls.

The Effects of Stress – Cortisol and how it Works

Cortisol Levels
Cortisol is often referred to as the Stress Hormone and is part of our flight-or- fight response. We evolved to cope with varying levels of stress throughout the day – something we often have little opportunity to change.

But these levels should be lowest at night to allow our bodies to recuperate and rejuvenate. Instead in today’s world we do not allow ourselves to de-stress before we go to sleep, encouraging our bodies to maintain a high level of cortisol while we sleep

Cortisol Over Secretion Linked With Obesity & Fat Production
The adrenal glands secrete the hormone cortisol as a reaction to stress, in conjunction with sleep-wake patterns. One of the functions of cortisol is to trigger a glucocorticoid effect – helping the body produce blood sugar from proteins. Excess glucose is then used for lipogenesis (fat production). Thus, numerous research studies have linked over secretion of cortisol with obesity and increased fat storage in the body.

Cortisol and Poor Eating Habits
Cortisol may also play a role in poor eating habits. Recently, researchers exploring eating disorders found that women who secreted higher levels of cortisol had a much greater tendency to snack on high-fat foods than did women who did not.

In general, adrenal dysfunction can lead to hypothyroidism, lowered metabolic rate, and weight gain.

Toxin Storage

Toxins are stored in fat cells—that is, embedded in body fat.

The more fat in your body, the more toxins you store. Stored toxins cause your cells and organs to become sluggish and inefficient. Toxins also attack and destroy cells and gene structures. They create an acidic internal environment that is vulnerable to fungi, bacteria, parasites, worms, viruses, and many other pathogens.

Organs and body systems under a toxic load lose their ability to metabolize and process fat effectively. When you ingest fewer toxins, your body will not need as much fat to store them and will quickly begin to let go of the excess. This process also assists in your bodies immunity response as the body also stores toxins where it is weak, making the weak area even weaker and eventually manifest into cyst or disease. An area left diseased for too long becomes difficult to repair.

Inflammation

We have come to understand that chronic inflammation is one of the leading contributors to diseases such as cancer and diabetes.

Inflammation protects the body by protecting it from foreign infections and toxins. We run into difficulty when gut bacteria becomes imbalanced, leading to chronic inflammation in the gut and other parts of the body. In effect, the body is attacking itself, creating an acidic environment and leading to many of the aforementioned health problems.

Research has identified a molecular receptor in the colon called GPR43 that acts to inhibit inflammation and signals your body to reduce inflammation. By activating healthy fermentation in the colon, Switch turns on GPR43; acting to reduce inflammation entering the body and reducing inflammation throughout the body.